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Martindale: The Complete Drug Reference June 2025

This update contains 25 new monographs and 14 existing monographs have been updated. Preparations have also been updated for 4 countries.

New Monographs

  • 11β-Methyl-19-nortestosterone is reported to be an anabolic androgenic steroid. It may be subject to abuse in sport.
  • 17α-Methylepitiostanol is reported to be an anabolic androgenic steroid that is a precursor of desoxymethyltestosterone. It may be subject to abuse in sport.
  • 2-Phenylpropylamine is an isomer of amfetamine that may be included in dietary supplements promoted for weight loss and athletic performance. The FDA do not consider it to be a dietary ingredient. It may be subject to abuse in sport.
  • 4-Fluoromethylphenidate is an analogue of methylphenidate. It may be subject to abuse in sport.
  • 9-Hydroxyfluorene is reported to be a stimulant that may be subject to abuse in sport.
  • Adrenosterone is reported to be an anabolic androgenic steroid that may be subject to abuse in sport.
  • BPC-157 is a 15-amino acid peptide that may be subject to abuse in sport.
  • Dimethandrolone is reported to be an anabolic androgenic steroid that may be subject to abuse in sport.
  • Elacestrant is an oestrogen antagonist that degrades the oestrogen receptor-α, and is used for the treatment of locally advanced or metastatic breast cancer in males and postmenopausal females.
  • Ethylphenidate is an analogue of methylphenidate. It may be subject to abuse in sport.
  • Fruquintinib is a tyrosine kinase inhibitor used in the treatment of metastatic colorectal cancer.
  • Lebrikizumab is a recombinant monoclonal antibody that is used for the treatment of moderate to severe atopic eczema.
  • Lecanemab is a recombinant humanised immunoglobulin G1 monoclonal antibody that binds to aggregated amyloid-beta. It is used in the treatment of mild cognitive impairment and mild dementia in Alzheimer’s disease.
  • Methylnaphthidate is an analogue of methylphenidate. It may be subject to abuse in sport.
  • MOTS-c is an AMP-activated protein kinase (AMPK) activator. It may be subject to abuse in sport.
  • Quizartinib is a tyrosine kinase inhibitor that targets FMS-like tyrosine kinase 3 (FLT3). It is used in the treatment of acute myeloid leukaemia with a FLT3 internal tandem duplication (ITD) mutation.
  • Ractopamine is reported to be a beta-adrenoceptor agonist used in some countries as an animal-feed additive to promote growth. It may be subject to abuse in sport.
  • Ryanodine receptor-1-calstabin complex stabilisers reduce calcium leakage from the sarcoplasmic reticulum of skeletal muscle cells, thereby improving muscle function. They may be subject to abuse in sport.
  • S-23 is reported to be a selective androgen receptor modulator (SARM). It may be subject to abuse in sport.
  • S-519 is reported to be an insulin mimetic that may be subject to abuse in sport.
  • S-597 is reported to be an insulin mimetic that may be subject to abuse in sport.
  • SR-9011 is reported to be a Rev-erbα agonist and may be subject to abuse in sport.
  • Trestolone is reported to be an anabolic androgenic steroid that may be subject to abuse in sport.
  • Troponin activators selectively activate the troponin complex, increasing the calcium sensitivity of troponin C and thereby increasing muscle contraction. They may be subject to abuse in sport.
  • YK-11 is reported to be a selective androgen receptor modulator (SARM). It may be subject to abuse in sport.

Selective Updates – some new, re-validated or changed information

Monographs

  • Aducanumab
  • Broom (formerly Scoparium)
  • Colchicine
  • Dandelion (formerly Taraxacum)
  • Elder (formerly Sambucus)
  • Flavonoids (formerly Flavonoid Compounds)
  • Hawthorn (formerly Crataegus)
  • Methenamine
  • Nettle (formerly Urtica)
  • Pelargonium (formerly Pelargonium Sidoides)
  • Pygeum (formerly Pygeum Africanum)
  • Rhodiola (formerly Rhodiola Rosea)
  • Sirolimus
  • Willow (formerly Salix)

 

Updated names, synonyms and codes; official standards; official preparations

  • Ph. Eur. 11.4

 

Proprietary Preparations and Manufacturers updated for the following countries and regions:

  • Portugal
  • Sweden
  • UK†
  • USA†

† Countries updated on an ongoing basis