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Martindale: The Complete Drug Reference March 2023 Update

This update contains 14 new monographs. Preparations have been updated for 4 countries.

New monographs:

  • Anifrolumab is a human monoclonal antibody Type 1 interferon receptor antagonist used in the treatment of systemic lupus erythematosus.
  • Asciminib, a BCR-ABL1 tyrosine kinase inhibitor specifically targeting the ABL myristoyl pocket (STAMP), is used for the treatment of chronic phase Philadelphia chromosome (Ph) positive chronic myeloid leukaemia (CML) including CML with a T315I mutation.
  • Casirivimab is a recombinant human monoclonal antibody with antiviral activity against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). It is used with imdevimab in the treatment and prevention of COVID-19 infection.
  • Clascoterone is an androgen receptor inhibitor used topically for the treatment of acne vulgaris.
  • Dostarlimab is a humanised immunoglobulin G4 monoclonal antibody that binds to PD-1. It is used for the treatment of solid tumours, including endometrial cancer, that are mismatch repair deficient (dMMR).
  • Entrectinib is a protein kinase inhibitor that is used in the treatment of solid tumours expressing a neurotrophic tyrosine receptor kinase (NTRK) gene fusion and ROS1-positive non-small cell lung cancer.
  • Faricimab is a humanised immunoglobulin G1 monoclonal antibody that binds to and inhibits both vascular endothelial growth factor A (VEGF-A) and angiopoietin-2 (Ang-2). It is used for the treatment of neovascular (wet) age-related macular degeneration and diabetic macular oedema.
  • Fostemsavir is a prodrug of temsavir, a HIV-1 entry inhibitor. It is used with other antiretrovirals for treatment of multidrug-resistant HIV-1 infection and AIDS in treatment-experienced patients.
  • Imdevimab is a recombinant human monoclonal antibody with antiviral activity against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). It is used with casirivimab in the treatment and prevention of COVID-19 infection.
  • Margetuximab is a monoclonal antibody directed against cell surface proteins produced by the human epidermal growth factor receptor 2 (HER2) gene; it is used for the treatment of HER2-positive metastatic breast cancer.
  • Mitapivat is a pyruvate kinase activator used in the treatment of haemolytic anaemia in patients with pyruvate kinase deficiency.
  • Tazemetostat is a selective inhibitor of histone methyltransferase EZH2 (enhancer of zeste homolog 2) used for the treatment of epithelioid sarcoma and follicular lymphoma.
  • Tebentafusp is a bispecific fusion protein that binds to both glycoprotein 100 on uveal melanoma cells and CD3 receptors on T-cells. It is used for the treatment of HLA-A*02:01-positive unresectable or metastatic uveal melanoma.
  • Tralokinumab is a human monoclonal antibody that is used for the treatment of moderate to severe atopic eczema.

Updated names, synonyms and codes; official standards; official preparations:

  • USP-NF 2022, Issue 2
  • USP-NF 2022, Issue 3

Proprietary Preparations and Manufacturers updated for the following countries and
regions:

  • Chile
  • Mexico
  • UK†
  • USA†

† Countries updated on an ongoing basis