BNF for Children August 2023 Update

This update contains 7 significant changes, 2 dose changes, 2 new monographs, 1 new preparation, and 1 deleted monograph.

Significant Changes:

• Adrenal insufficiency: updated guidance for management.
  Corticosteroids, replacement therapy: title change to Adrenal insufficiency.
  Direct-acting oral anticoagulants (DOACs): paediatric formulations [MHRA/CHM advice] (advice in rivaroxaban).
• Drugs that cause first dose hypotension, drugs that cause peripheral neuropathy, and drugs that cause hyponatraemia: pharmacodynamic effects drug groups revalidated and updated; see Appendix 1 interactions.
• Drugs that cause thromboembolism: pharmacodynamic effects drug group deleted from Appendix 1 interactions.
• Immunisation schedule: updated guidance for influenza immunisation.
  Influenza vaccine: updated guidance for immunisation.

Dose Changes:

• Amiodarone hydrochloride [update to dosing for supraventricular and ventricular arrhythmias].
• Hydrocortisone [update to dosing for adrenal crisis in children].

New Monographs:

• Filsuvez® [birch bark extract].
• Oxlumo® [lumasiran].

New Preparation:

• Benzydamine hydrochloride 0.3% oromucosal spray.

Deleted Monograph:

• Tipranavir.