Agilio: Diagnosis and Treatment Guidance
13 May 2026
Agilio: Diagnosis and Treatment Guidance
This update contains 5 significant changes and 6 minor changes….
Agilio: Diagnosis and Treatment Guidance
Practical clinical guidance for common conditions and symptoms
Covering over 370 clinical topics for use in primary care, Agilio: Diagnosis and Treatment Guidance supports confident decision-making at the point of care. Available to customers outside of the UK.
Providing trusted, concise summaries of current evidence and prescribing information to support clinical decisions on a patient’s diagnosis and treatment.
Referenced and linked to source evidence and covering over 1,200 clinical presentations or patient scenarios, this guidance supports health professionals to assess symptoms, diagnose the disease and identify treatment options.
- 370+
- Clinical topics
- 1,200+
- Clinical presentations
- ~7
- New topics produced each year
Helping to deliver better patient outcomes
Evidence-based and independent guidance
Reach a diagnosis and prescribe safely
Consult patient scenarios for practical clinical management
Offer safe and effective treatment options
Create local protocols and guidance
Clinical topics commissioned and accredited by NICE
Transparent and rigorous content development process
Easily accessible at the point of need
Latest knowledge updates
13 May 2026
Agilio: Diagnosis and Treatment Guidance
This update contains 5 significant changes and 6 minor changes.
Significant Changes:
- Breast pain — reviewed. A literature search was conducted in April 2026 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic. No major changes to recommendations have been made. A new section on referral has been added. More emphasis was given to the lack of association between cyclical breast pain and breast cancer in light of recent additional evidence and current national UK referral priorities and policies.
- Chest pain — reviewed. A literature search was conducted in January 2026 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. The recommendations on pre-hospital management of acute heart failure have been updated in line with NICE guidance on the diagnosis and management of acute heart failure NICE, 2021.
- Hiccups — reviewed. A literature search was conducted in March 2026 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. No changes have been made to the recommendations.
- Red eye — reviewed. A literature search was conducted in February 2026 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. No change to clinical recommendations has been made.
- Scrotal pain and swelling — reviewed. A literature search was conducted in April 2026 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. No major changes to the recommendations have been made.
Minor Changes:
- Anticoagulation — minor update. Advice for switching between DOACs clarified.
- CKD — minor update. Minor error corrected. Recommendations on the use of antiplatelet therapy in line with NICE and KDIGO.
- Dementia — minor update. Clarification of clinical differences between DLB and Parkinsons dementia.
- Hypokalaemia — minor update. Minor changes to wording in Primary care management.
- NSAIDs prescribing issues — minor update. Broken link updated.
- Ulcerative colitis — minor update. Broken link updated.
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14 April 2026
Agilio: Diagnosis and Treatment Guidance
This update contains 5 significant changes and 9 minor changes….
14 April 2026
Agilio: Diagnosis and Treatment Guidance
This update contains 5 significant changes and 9 minor changes.
Significant Changes:
- Bruising— reviewed. A literature search was conducted in February 2026 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. The topic has been updated in line with current evidence in the literature. No major changes to the recommendations have been made.
- Chlamydia – uncomplicated genital— reviewed. A literature search was conducted in December 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic. The structure of the topic was changed to improve clarity.
- Palpitations— reviewed. A literature search was conducted in January 2026 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. Brief information about the use of patient-activated electrocardiogram (ECG) devices has been added. No major changes to the recommendations have been made.
- Postnatal care— reviewed. A literature search was conducted in February 2026 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. No major changes to the recommendations have been made.
- Whitlow (staphylococcal and herpetic) — reviewed. A literature search was conducted in February 2026 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic. There have been minor structural changes to the topic and the evidence supporting the recommendations has been updated in line with the identified literature. Minor changes have been made to the prescribing information sections, aligning the information with the cited prescribing information references. There have been no major changes to the recommendations.
Minor Changes:
- Asthma— minor update. Broken links have been amended, and the wording has been slightly changed in the section on the management of newly diagnosed asthma.
- Diabetes – type 2 — minor update. Updated to align with the 2026 update to NICE guidance Type 2 Diabetes in adults: management.
- Heart failure – chronic — minor update. Typographical error corrected.
- Insulin therapy in type 2 diabetes— minor update. Aligned with the 2026 update to NICE guidance Type 2 diabetes in adults: management.
- Measles — minor update. Wording changed in the diagnosis section to clarify the use of HPT oral fluid kits as a surveillance tool, highlighting that the confirmation of diagnosis through laboratory infection is the responsibility of the clinician.
- Prostate cancer— minor update. Update to Assessment section.
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10 March 2026
Agilio: Diagnosis and Treatment Guidance
This update contains 5 significant changes and 4 minor changes….
10 March 2026
Agilio: Diagnosis and Treatment Guidance
This update contains 5 significant changes and 4 minor changes.
Significant Changes:
Achilles tendinopathy — reviewed. A literature search was conducted in November
2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key
randomized controlled trials published since the last revision of the topic. The
Prescribing information section was deleted and a link to the Prodigy topic on
Analgesia – mild-to-moderate pain has been included in the Management section.
The information about Achilles tendon rupture has been moved to the Complications
section to aid navigation. No major changes to clinical recommendations have been
made.
Giant cell arteritis — reviewed. A literature search was conducted in November 2025
to identify evidence-based guidelines, UK policy, systematic reviews, and key
randomized controlled trials published since the last revision of this topic. No major
changes to recommendations have been made. An Assessment node has been added
to the Diagnosis section in line with current Prodigy style. The section on Prescribing
information has been removed and a link provided to the Prodigy topic on
Corticosteroids – oral.
Mastitis and breast abscess — reviewed. A literature search was conducted in
December 2025 to identify evidence-based guidelines, UK policy, systematic reviews,
and key randomized controlled trials published since the last revision of this topic. No
major changes to the recommendations have been made.
Neuropathic pain – drug treatment — reviewed. A literature search was conducted
in December 2025 – January 2026 to identify evidence-based guidelines, UK policy,
systematic reviews, and key randomized controlled trials published since the last
revision of this topic. Additional information and clarification have been added
relating to risks of dependence and prescribing off-label. There has been minor
reorganization of the prescribing section. There have been no major changes to the
recommendations.
Squint in children — reviewed. A literature search was conducted in November 2025
to identify evidence-based guidelines, UK policy, systematic reviews, and key
randomized controlled trials published since the last revision of the topic. There were
no significant changes to the topic recommendations. Minor structural changes have
been made to the topic to align the recommendations with the most recent
literature.
Minor Changes:
Acne vulgaris — minor update. The recommendation of two independent
prescribers of isotretinoin therapy for under 18s has been updated to a single
prescriber in line with an SPC update.
Compression stockings — minor update to align information regarding ABPI with
contemporary guidance.
Gallstones — minor update in the wording of risk factors for gallstones.
Sepsis — minor update. Revised the sepsis six in line with the Sepsis Trust manual
7th edition.
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10 February 2026
Agilio: Diagnosis and Treatment Guidance
This update contains 6 significant changes and 12 minor changes….
10 February 2026
Agilio: Diagnosis and Treatment Guidance
This update contains 6 significant changes and 12 minor changes.
Significant Changes:
- Contraception – IUS/IUD — reviewed. A literature search was conducted in September 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic. More detail has been added to the sections on follow-up advice, new-onset pelvic pain and uterine perforation in line with guidance from the College of Reproductive and Sexual Health. No major changes to recommendations have been made.
- Gilbert’s syndrome — reviewed. A literature search was conducted in October 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. No major changes to the recommendations have been made.
- Itch – widespread — reviewed. A literature search was conducted in November 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. The recommendations have been updated in line with current evidence in the literature.
- Obstructive sleep apnoea syndrome — minor update. Table 1 in the treatment section has been updated for clarity. The recommendations remain the same.
- Platelets – abnormal counts and cancer — reviewed. A literature search was conducted in October 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last version of this topic. The topic structure has been amended to aid navigation and reduce duplication. The management sections have been expanded and updated in line with current evidence in the literature.
- Support for adult carers — reviewed. A literature search was conducted in October 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. No major changes to recommendations have been made, but the topic has been restructured for clarity.
Minor Changes:
- Bipolar disorder — minor update. Revised wording regarding monitoring of hba1c and prolactin for some atypical antipsychotics.
- Boils, carbuncles, and staphylococcal carriage — minor update. Minor typographical error corrected.
- Cervical screening — minor update. Section ‘What is the Cervical Screening Programme’ also updated to a 5 year recall.
- Child maltreatment — minor update. Definition for whether a child is “independently mobile” has been added, in line with the December 2025 update to Child maltreatment: when to suspect maltreatment in under 18s.
- Chronic obstructive pulmonary disease— minor update. Table 1 in the treatment section has been updated for clarity. The recommendations remain the same.
- Hypertension — minor update. Minor change to the order of referral criteria in the management section.
- Influenza – seasonal— minor update. Information on when antivirals can be prescribed has been clarified.
- Prostate cancer — minor update. Added detail on the range of potential false negative testing for PSA.
- Psychosis — minor update. Revised wording regarding monitoring of hba1c and prolatin for some atypical antipsychotics.
- Shingles — minor update. Information on eligible cohorts for shingles vaccination has been updated in line with updated NHS guidance.
- Smoking cessation — minor update. Added detail to advise that although e-cigarettes cannot currently be prescribed or supplied by NHS smoking cessation clinics the majority of local authority smoking cessation clinics do provide them as part of a harm reduction approach.
- Urticaria — minor update. Added more information on titrating dose of antihistamines in the prescribing section.
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9 December 2025
Agilio: Diagnosis and Treatment Guidance
This update contains 4 significant changes and 8 minor changes….
9 December 2025
Agilio: Diagnosis and Treatment Guidance
This update contains 4 significant changes and 8 minor changes.
Significant Changes:
- Analgesia – mild-to-moderate pain — reviewed. A literature search was
conducted in July 2025 to identify evidence-based guidelines, UK policy,
systematic reviews, and key randomized controlled trials published since
the last version of this topic. Changes have been made to
recommendations in line with the guideline from the National Institute for
Health and Care Excellence (NICE) on chronic pain, and in line with
publication of additional warnings from the Medicines and Healthcare
products Regulatory Agency (MHRA) on the risk of dependence and
addiction from prolonged use of opioids for non-cancer pain. - Contraception – emergency — reviewed. A literature search was
conducted in August 2025 to identify evidence-based guidelines, UK
policy, systematic reviews, and key randomized controlled trials published
since the last revision of the topic. Minor changes have been made to align
with updated guidance from the College of Sexual and Reproductive
Healthcare (CoSRH) (formerly known as the Faculty of Sexual and
Reproductive Healthcare). Text has been updated to reflect a revised
recommendation from CoSRH which states that no interruption of
breastfeeding is necessary following a single dose of ulipristal acetate
when given for emergency contraception CoSRH, 2025. - Hyponatraemia — reviewed. A literature search was conducted in
September 2025 to identify evidence-based guidelines, UK policy,
systematic reviews and key randomized controlled trials published since
the last version of this topic. No major changes to clinical
recommendations have been made. - Macular degeneration – age-related — reviewed. A literature search
was conducted in September 2025 to identify evidence-based guidelines,
UK policy, systematic reviews, and key randomized controlled trials
published since the last revision of this topic. No major changes to the
recommendations have been made.
Minor Changes:
- Autism in adults — minor update. Added additional information
regarding possible undiagnosed autism in older adults. - Benign paroxysmal positional vertigo — minor update. A minor
typographical error has been corrected. - Constipation — minor update. Information that naldemedine is an option
for people with short-duration opioid-induced constipation has been added
in line with the nice technology appraisal naldemedine for treating opioid-
induced constipation. - Influenza – seasonal — minor update. Updated to align with the updated
nice guideline ng253 suspected sepsis in people aged 16 or over.
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11 November 2025
Agilio: Diagnosis and Treatment Guidance
This update contains 8 significant changes and 11 minor changes….
11 November 2025
Agilio: Diagnosis and Treatment Guidance
This update contains 8 significant changes and 11 minor changes.
Significant changes:
- Anticoagulation – oral —reviewed. A literature search was conducted in May 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic. No major changes to clinical recommendations have been made.
- Contraception – progestogen-only methods — reviewed. A literature search was conducted in June 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic. No major changes to recommendations have been made. Minor changes have been made to align with updated guidance from the College of Sexual and Reproductive Healthcare (formerly known as the Faculty of Sexual and Reproductive Healthcare).
- Diabetes – type 1 — reviewed. A literature search was conducted in June 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. The recommendations have been updated in line with evidence in current literature, including the use of diabetes-specific autoantibody testing in adults at diagnosis, and when to suspect hypoglycaemia. The sections on insulin therapy, self-monitoring of blood glucose, and management of hypoglycaemia have been removed, and links to the Prodigy topic on Insulin therapy in Type 1 diabetes have been provided.
- Earwax — reviewed. A literature search was conducted from September to October 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic. No significant changes to clinical recommendations have been made.
- HIV infection and AIDS — reviewed. A literature search was conducted in August 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last version of this topic. The topic has been restructured for clarity, and recommendations have been updated in line with current evidence and guidance.
- Mental health in students — reviewed. A literature search was conducted in August 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic. There have been minor structural changes to the topic, updates to the background information, and basis for recommendation sections in line with the identified literature.
- Osgood-Schlatter disease — reviewed. A literature search was conducted in September 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. No major changes to recommendations have been made.
- Tennis elbow — reviewed. A literature search was conducted in August 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic. No major changes to recommendations have been made.
Minor changes:
- Anaemia – iron deficiency— minor update. Added information about normal haemoglobin and low ferritin levels in menstruating pre-menopausal women who may benefit from referral for intravenous iron therapy, when symptomatic.
- Antenatal care – uncomplicated pregnancy — minor update. The information about which immunizations to discuss at the booking appointment has been updated to include respiratory syncytial virus (RSV), and COVID vaccination has been removed as pregnant women are no longer included in the vaccination programme.
- Bipolar disorder — minor update. Typographical error corrected.
- Cellulitis – acute — minor update. Added information on drug interaction between rifampicin and doxycycline.
- Chronic obstructive pulmonary disease — minor update. Changes have been made to the recommendation on when to consider referral to a specialist in respiratory medicine to consider starting oral prophylactic antibiotic therapy in line with NICE guideline Chronic obstructive pulmonary disease in over 16s: diagnosis and management and the British Thoracic Society Guideline for the use of long-term macrolides in adults with respiratory disease.
- Hypertension — minor update. Removed interaction between calcium channel blockers and theophylline and aminophylline to align with the BNF drug monograph.
- Leg ulcer – venous — minor update. Added information on drug interaction between rifampicin and doxycycline.
- Rosacea — minor update. Added information on drug interaction between rifampicin and doxycycline.
- Sensory neuropathy — minor update. The information that a serum protein electrophoresis with immunofixation test can be considered for people with sensory neuropathy has been moved to the section on additional investigations.
- Sinusitis — minor update. Added information on drug interaction between rifampicin and doxycycline.
- Urethritis – male — minor update. Added information on drug interaction between rifampicin and doxycycline.
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