Martindale: The Complete Drug Reference March 2025 Update

This update contains 4 new monographs and 29 existing monographs have been updated. Preparations have also been updated for 4 countries.

New Monographs

• Olutasidenib is an inhibitor of isocitrate dehydrogenase-1 (IDH1) that is used for the treatment of relapsed or refractory acute myeloid leukaemia with an IDH1 mutation.
• Omaveloxolone is an activator of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, which is involved in the cellular response to oxidative stress. It is used for the treatment of Friedreich’s ataxia.
• Pirtobrutinib is an inhibitor of Bruton’s tyrosine kinase that is used in the treatment of relapsed or refractory mantle cell lymphoma, and relapsed or refractory chronic lymphocytic leukaemia or small lymphocytic lymphoma.
• Zilucoplan is a synthetic macrocyclic peptide that acts as a complement blocker by inhibiting complement activation at both the C5 protein and the C5b protein moiety. It is used in the treatment of generalised myasthenia gravis.

Selective Updates – some new, re-validated or changed information

Monographs

• Artichoke (formerly Cynara)
• Asafoetida (formerly Asafetida)
• Bilberry (formerly Myrtillus)
• Black Cohosh (formerly Cimicifuga)
• Bloodroot (formerly Sanguinaria)
• Blue Flag (formerly Iris Versicolor)
• Bogbean (formerly Menyanthes)
• Burdock (formerly Lappa)
• Couch Grass (formerly Couch-grass)
• Cramp Bark (formerly Viburnum Opulus)
• Eyebright (formerly Euphrasia)
• False Unicorn (formerly Helonias)
• Goat’s Rue (formerly Galega Officinalis)
• Goldenseal (formerly Hydrastis)
• Holy Thistle (formerly Cnicus Benedictus)
• Hops (formerly Lupulus)
• Horse-chestnut (formerly Aesculus)
• Horsetail (formerly Equisetum)
• Lady’s Slipper (formerly Cypripedium Pubescens)
• Lime Flower (formerly Tilia)
• Marshmallow (formerly Althaea)
• Methylsulfonylmethane (formerly Dimethyl Sulfone)
• Passionflower (formerly Passion Flower)
• Pumpkin Seed (formerly Cucurbita)
• Rilpivirine
• Tivozanib
• Tribulus (formerly Tribulus Terrestris)
• White Horehound (formerly Marrubium)
• Yarrow (formerly Achillea)

Updated names, synonyms and codes; official standards; official preparations

• ATC and ATC (veterinary) codes 2025
• BP 2024
• Eur. 11.3
• WADA 2025 processing

Proprietary Preparations and Manufacturers updated for the following countries and regions:

• Hong Kong
• Venezuela
• UK^†
• USA^†

† Countries updated on an ongoing basis