Martindale: The Complete Drug Reference December 2024 Update

This update contains 8 new monographs and 29 existing monographs have been updated. Preparations have also been updated for 5 countries.

New Monographs

Durlobactam is a non-beta lactam, beta-lactamase inhibitor. It is given with sulbactam in the treatment of hospital-acquired pneumonia, including ventilator-associated pneumonia.
Leniolisib is a selective phosphoinositide-3 kinase (PI3K) δ inhibitor used for the treatment of activated PI3Kδ syndrome (APDS).
Maralixibat is a reversible selective inhibitor of the ileal bile acid transporter. It is used for the treatment of cholestatic pruritus associated with either Alagille syndrome or progressive familial intrahepatic cholestasis.
Palovarotene is a retinoid used to reduce further heterotopic ossification in adults and children with fibrodysplasia ossificans progressiva.
Pegunigalsidase alfa is a recombinant form of alpha galactosidase A. It is used as enzyme replacement therapy in the treatment of Fabry disease.
Relebactam is a non-beta-lactam, beta-lactamase inhibitor. It is given as a fixed-dose combination preparation with cilastatin and imipenem in the treatment of infections where beta-lactamase production is suspected.
Rezafungin is an echinocandin antifungal used in the treatment of candidaemia and invasive candidiasis.
Rozanolixizumab is a humanised IgG4 monoclonal antibody that binds to the neonatal Fc receptor (FcRn). It is used for the treatment of generalised myasthenia gravis in adults who have antibodies for either the acetylcholine receptor (AChR) or muscle-specific tyrosine kinase (MuSK).

New salts or related derivatives added to existing monographs

Selective Updates – some new, re-validated or changed information

Monographs

2C-B (formerly 4-Bromo-2,5-dimethoxyphenylethylamine)
4-Methylamfetamine (formerly p-Methylamfetamine)
Anhydrous Silicon Dioxide (formerly Colloidal Silicon Dioxide)
Chitosan (formerly Poliglusam)
Chitosan Hydrochloride (formerly Poliglusam Hydrochloride)
Clofazimine
CN Gas (formerly Chloroacetophenone)
Cytisinicline
Glyceryl Monooleate (formerly Glyceryl Mono-oleate)
Hydrated Silicon Dioxide (formerly Silicon Dioxide)
Landiolol hydrochloride
Laureth-4 (formerly Laureth 4)
Liquid Maltitol (formerly Maltitol Syrup)
Mephedrone (formerly 4-Methylmethcathinone)
Methyl Methacrylate (formerly Methylmethacrylate)
Methylenedioxymetamfetamine (formerly Methylenedioxymethamfetamine)
Octyl Gallate (formerly Octil Gallate)
Oleth-10 (formerly Polyoxyl 10 Oleyl Ether)
Pyritidium Bromide (formerly Pyrithidium Bromide)
Quinupristin with Dalfopristin (formerly Quinupristin/Dalfopristin)
Sucrose Octaacetate (formerly Sucrose Octa-acetate)
Sulbactam
Talc (formerly Purified Talc)
TMA-2 (formerly 2,4,5-Trimethoxyamfetamine)
Tricaprilin (formerly Tricaprylin)
Trierucin (formerly Glyceryl Trierucate)
Triolein (formerly Glyceryl Trioleate)
Voclosporin is an analogue of ciclosporin that is used in the management of active lupus nephritis.

Updated names, synonyms and codes; official standards; official

Preparations

Proprietary Preparations and Manufacturers updated for the following countries and regions:

† Countries updated on an ongoing basis