BNF for Children April 2023 Update

This update contains 1 significant change, 3 dose changes, 5 new monographs, and 1 deleted monograph.

Significant Change:

• Metolazone (Xaqua®): exercise caution when switching patients between metolazone preparations [MHRA/CHM advice].

Dose Changes:

• Cefotaxime [update to dosing for emergency treatment of suspected bacterial meningitis or meningococcal disease, before urgent transfer to hospital].
• Harvoni® (ledipasvir with sofosbuvir) [update to include dosing in children from 3 years old].
• Sovaldi® (sofosbuvir) [update to include dosing in children from 3 years old].

New Monographs:

• Epclusa® [sofosbuvir with velpatasvir].
• Forxiga® [dapagliflozin].
• Lamzede® [velmanase alfa].
• Nexviadyme® [avalglucosidase alfa].
• Rezurock® [belumosudil].

Deleted Monographs:

• Bleomycin.