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BNFC for Children September 2024 Update

This update contains 5 significant changes, 4 dose changes, 1 new preparation, 1 deleted monograph and 2 deleted preparations.

Significant Changes:

  • Carbamazepine (Tegretol® 100 mg/5 mL Liquid): temporary stock-out and update to posology (reduction of maximum daily dose) [MHRA/CHM advice].
  • Drugs that cause sedation and drugs with CNS depressant effects: pharmacodynamic effects drug groups combined and renamed as drugs with CNS effects; see Interactions.
  • Gonadotrophin-releasing hormone analogues: new restrictions on use for puberty suppression (see example in gonadorelin).
  • Topiramate (Topamax®): introduction of new safety measures, including a Pregnancy Prevention Programme [MHRA/CHM advice].
  • Warfarin sodium: be alert to the risk of drug interactions with tramadol [MHRA/CHM advice].

Dose Changes:

  • Calcium gluconate [update to dosing for acute severe hyperkalaemia].
  • Ivacaftor with tezacaftor and elexacaftor [update to dosing].
  • Lebrikizumab [update to dosing].
  • Rosuvastatin [update to dose adjustments due to interactions with belumosudil].

New Preparations: Ivermectin.

Deleted Monographs: Colecalciferol with calcium phosphate.

Deleted Preparations: Creon 40000® [pancreatin]; Pancrease HL® [pancreatin].”